2023 USA – European Exposome Symposium

Exposomic Approaches to Prevent the Health Impacts of Climate Change

The Mount Sinai Institute for Exposomic Research and the University of Brescia Co-host the 2023 USA-European Exposome Symposium in Italy

This collaboration marks the sixth exposome symposium organized by the Mount Sinai Institute for Exposomic Research since 2018, and the third in partnership with the University of Brescia.

The theme of this symposium focused on “Exposomic Approaches to Prevent the Health Impacts of Climate Change,” and the keynote presentation “A Vision for Operationalizing Exposomics” was delivered by Richard Woychik, PhD, Director of the United States National Institute of Environmental Health Sciences. The symposium brought together leading US- and European-based researchers and trainees in the field of exposomics and environmental health to share their latest findings and insights. The exposome refers to the totality of exposures that an individual experiences over their lifetime, including environmental, dietary, and lifestyle factors.  

In addition to exploring the role of climate change in exposomic research programs, the meeting offered an opportunity to discuss more broadly the challenges of generating high-quality, untargeted chemical assays, as well as a discussion of how to use computer science and mapping to generate novel, exposure data, and other new methods in the field. Finally, the symposium presented both the strengths of including exposomics in human research and the challenges inherent to study design, and statistical and bioinformatic analysis of exposomic data.

The symposium planning committee included:

  • Robert Wright, MD, MPH, Co-Director, Mount Sinai Institute for Exposomic Research
  • Rosalind Wright MD, MPH, Co-Director, Mount Sinai Institute for Exposomic Research
  • Manish Arora, BDS, MPH, PhD, Director, Mount Sinai Institute for Exposomic Research Laboratories
  • Donatella Placidi, MD, Professor of Occupational Medicine in the Department of Medico-Surgical Specialties, Radiological Sciences and Public Health at the University of Brescia
  • Yuxia Cui, PhD, Health Scientist Administrator at the National Institute of Environmental Health Sciences (NIEHS)
  • Gary W. Miller, PhD, Vice Dean for Research Strategy and Innovation and Professor of Environmental Health Sciences in the Mailman School of Public Health

Posters winners included:

1st Place: Jeroen de Bont, PhD, Postdoctoral fellow at Karolinska Institutet
“Urban exposome and stroke incidence across Europe”

2nd Place: Kateřina Coufalíková, PhD, and Štěpán Koudelka, PhD, Researchers at RECETOX at Masaryk University
“Central Czech node of European Environmental Exposure Assessment Research Infrastructure (EIRENE-CZ)”

3rd Place: Camilla Guerrini, PhD Candidate at Institut d’Investigació Sanitària Pere Virgili (IISPV)
“Advanced metabolomics strategies to characterise the early-life exposome”

Two 4th Place awards were given to:

Kaustubh Chakradeo, PhD Candidate at the University of Copenhagen
“Malaria Prediction with Remote Sensing”

Paola Monti, PhD Candidate at the EPIGET Lab, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
“Effect of environmental and lifestyle factors on circulating oncomiRs carried by extracellular vesicles in a population of subjects with overweight or obesity”

The Icahn School of Medicine at Mount Sinai and the University of Brescia have a longstanding partnership with many collaborative research projects. Brescia is a heavily industrialized province of northern Italy where high levels of heavy metals such as manganese, lead, and copper have been detected in deposited dust samples collected from residential households.  This region is the focus of the Mount Sinai-University of Brescia PHIME (Public Health Impact of Metals Exposure) study, which has demonstrated adverse neurodevelopmental and other health outcomes.

The symposium received support from the Mount Sinai Human Health Exposure Analysis Resource (HHEAR) Lab Hubs and Data Center (U2CES026561, U2CES026555) (U2CES030859); HEALS, the Mount Sinai Environmental Health Sciences Core Center (P30ES023515); Mount Sinai ConduITS Clinical and Translational Science Award (CTSA) Program (UL1TR001433).

Additional support was provided by LinusBio.

About the Institute for Exposomic Research

The Institute for Exposomic Research at the Icahn School of Medicine at Mount Sinai envisions a world where we prevent disease with environmental origins and improve health outcomes for all, from preconception, pregnancy, and the earliest stages of child development to adulthood and retirement age. Our mission is to understand how environmental exposures affect health, disease, and development and to translate that knowledge into new strategies for prevention and treatment. Our approach is holistic, encompassing the chemical, nutritional, and social environments and the interrelationships among them. We aim to cultivate the public consciousness necessary to make meaningful changes in policies and practices to protect health and build healthier and more just communities where we live, play, and work. We strive to accomplish this mission while training the next generation of health professionals across multiple disciplines and in collaboration with practitioners from across the Mount Sinai Health System and beyond.  For more information, visit https://mountsinaiexposomics.org/