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Sapporo Exposome Symposium

Aging and the Exposome:
Research Implications for Alzheimer’s Disease and Related Dementias

This scientific symposium held at Hokkaido University from May 27-29, 2024 addressed how exposomic science holds the potential to revolutionize the study of Alzheimer’s disease and related dementias (ADRD).  The meeting brought together leading scientists and trainees from throughout Asia and the United States to share research findings, discuss the use of computational analytics and artificial intelligence / machine learning in analyzing results of large, multi-dimensional data sets, and discuss translational interventions and policies needed to reduce the effects of the environment on ADRD. 

Aging and the Exposome: Questions and Implications for Longevity
R. Sean Morrison, MD (Mount Sinai)

Exposomics in Clinical Research

Robert O. Wright, MD, MPH (Mount Sinai)

Prenatal Chemical Exposures on Child Neurodevelopment, Atsuko Ikeda, PhD (Hokkaido University)

Building Frameworks that Operationalize Exposomics
Rick Woychik, PhD (NIEHS)

Temporal Exposome Sequencing to Develop Biomarkers for ALS, Manish Arora, BDS, MPH, PhD (Mount Sinai)

A Pathway to Precision Aging

Richard Kwok, PhD (NIEHS)

Exposome as seen through a Planetary Health Framework, Chiho Watanabe (Nagasaki University)

Metabolomic Epidemiology and the Exposome
Craig Wheelock (Karolinska Institute)

What We Can Do to Utilize Results from Cohort Studies
Shoji Nakayama, MD, PhD (NIES/Japan)

Exposome Research for Health Economic Evaluation
Ruoyan Gai, PhD (Nagasaki University)

The Neighborhoods Study: Linking Social Exposome to Neurobiology, Amy Kind, MD, PhD (University of Wisconsin)

Exposome Assessment in the Digital Era

Rhoda Au, PhD (Boston University)

Perspective of Exposome Research on Birth Cohort Studies
Yu Ait Bamai PhD (Hokkaido University)

Neural Exposome Perspectives from the US NINDS
David Jett, PhD (NINDS)

Studies on Air Pollution and Late-Life Neurodegenerative Disorders, Mihye Lee, ScD (St. Luke’s International University)

The Role of Human Aging in Linking Environmental Exposures and Brain Health
Xu Gao, PhD (Peking University)

Exposomic Analysis in Two Multiethnic Cohorts of Alzheimer’s Disease
Gary Miller, PhD (Columbia University)

Aging and Frailty among the World Trade Center General Responder Cohort
William Hung, MD, MPH (Mount Sinai)

Exposomic Mixture Effect
Mingliang Fang, PhD (Fudan University)

Effects of Environmental Mixtures on the Elderly, Joel Schwartz, PhD (Harvard Uni)

What We Can Do to Utilize Results from Cohort Studies
Shoji Nakayama, MD, PhD (NIES/Japan)

Exposome Research for Health Economic Evaluation
Ruoyan Gai, PhD (Nagasaki University)

This symposium is organized by the Mount Sinai Institute for Climate Change, Environmental Health, and Exposomics. It is supported by Linusbio, the City of Sapporo, and by several grants from institutes within the National Institutes of Health (NIH): grant #R13AG087672 and #P30AG028741 from the National Institute on Aging (NIA), grant #P30ES023515 from the National Institute of Environmental Health Sciences (NIEHS), and grant #UL1TR004419 from the Clinical and Translational Science Awards (CTSA) Program, which is part of the National Center for Advancing Translational Sciences (NCATS).

We thank the many faculty and staff at Hokkaido University for their support during the symposium, especially:

Faculty of Health Sciences
Center for Environmental and Health Sciences
Atsuko Ikeda, PhD
Yu Ait Bamai, PhD
Kanae Abe
Rahel Mesfin Ketema, PhD
Pol. Capt. Pitsanu Khamnuan, MSN, RN
Megasari Marsela, DVM, PhD
Wataru Murase
Ayaka Yasuda
Yi Zeng, PhD