27-29 May 2024
Aging and the Exposome: Research Implications for Alzheimer’s Disease and Related Dementias
Location: Hokkaido University Conference Hall
Address: Kita 8, Nishi 5, Kita-ku, Sapporo, Hokkaido, Japan
Day #1 – Monday, 27 May 2024
10:30 am – 12:00 pm
Pre-Symposium Workshop: Introduction to GIS in Environmental Epidemiology and Exposomic Research
Itai Kloog, PhD, Professor, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, USA
Mike He, PhD, Postdoctoral Fellow, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, USA
Shoji Nakayama, MD, PhD, Deputy Director, Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Japan
12:00 pm
Check in/arrival (Lunch available)
1:00 pm
Welcome Remarks
Shoji Nakayama, MD, PhD, Deputy Director, Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Japan
Robert O. Wright, MD, MPH, Chair and Ethel H. Wise Professor of Community Medicine, Department of Environmental Medicine , Icahn School of Medicine at Mount Sinai, USA
Taro Yamauchi, PhD, Advisor to the President of Hokkaido University, Director of the Center for Environmental and Health Sciences, and Professor of Faculty of Health Sciences, Hokkaido University, Japan
1:30 pm
Exposome as seen through a Planetary Health Framework
Chiho Watanabe, PhD, Professor and former Dean of Interfaculty Initiative in Planetary Health, Nagasaki University, Japan
2:00 pm
Applying the Exposome Framework to Advance Alzheimer’s Disease and Related Dementias Research: A Pathway to Precision Aging
Richard Kwok, PhD, Program Director, Population Studies and Genetics Branch, Division of Neuroscience, National Institute on Aging (NIA), USA
2:30 pm
Aging and the Exposome: Unanswered Questions and Implications for Longevity
R. Sean Morrison, MD, FAAHPM, Ellen and Howard C. Katz Professor and Chair, Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, USA
3:00 pm
Break
3:30 pm
Prenatal Chemical Exposures on Child Neurodevelopment: Current Findings and Implementation for Future Diseases
Atsuko Ikeda, PhD, Professor, Faculty of Health Sciences and Adjunct Faculty, Center for Environmental and Health Sciences and One Health Research Center, Hokkaido University, Japan
4:00 pm
Metabolomic Epidemiology and the Exposome – New Approaches for Personalized Medicine of Complex Diseases
Craig E. Wheelock, PhD, Principal Researcher, Institute of Environmental Medicine, Karolinska Institute, Sweden
4:30 pm
Effects of Environmental Mixtures on the Elderly
Joel Schwartz, PhD, Professor of Environmental Epidemiology, Harvard T.H. Chan School of Public Health, USA
5:00 pm
End of day #1, attendees have a free evening.
Tuesday 28 May
9:20 am
Welcome
9:30 am
Building Frameworks that Operationalize Exposomics and Enable Precision Environmental Health
Rick Woychik, PhD, Director, National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program, USA
10:00 am
Exposomics in Clinical Research
Robert O. Wright, MD, MPH, Chair and Ethel H. Wise Professor, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, USA
10:30 am
The Neighborhoods Study: Linking Social Exposome to Neurobiology
Amy J.H. Kind, MD, PhD, Associate Dean for Social Health Sciences and Programs, Executive Director, Wisconsin Partnership Program, Director, UW Center for Health Disparities Research (CHDR), Professor, Department of Medicine, Division of Geriatrics, University of Wisconsin School of Medicine and Public Health
11:00 am
Poster Session and Lunch
1:00 pm
Beyond Associations: What We Can Do to Utilize Results from Cohort Studies
Shoji Nakayama, MD, PhD, Deputy Director, Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Japan
1:30 pm
Exposome Assessment in the Digital Era
Rhoda Au, PhD, Professor of Anatomy and Neurobiology, Neurology, Medicine and Epidemiology, Boston University Chobanian & Avedisian School of Medicine and School of Public Health, USA
2:00 pm
Perspective of Exposome Research on Birth Cohort Studies
Yu Ait Bamai, PhD, Associate Professor, Center for Environmental and Health Sciences, Hokkaido University, Japan, and Visiting Researcher, University of Antwerp, Belgium
2:30 pm
Temporal Exposome Sequencing to Develop Biomarkers for Amyotrophic Lateral Sclerosis
Manish Arora, BDS, MPH, PhD, Edith J. Baerwald Professor and Vice Chairman of the Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, and Co-Founder and CEO, LinusBio, USA
3:00 pm
Break
3:30 pm
Alzheimer’s Disease and Related Dementias: Neural Exposome, Perspectives from the U.S. National Institute of Neurological Disorders and Stroke
David A. Jett, PhD, Director, Office of Neural Exposome and Toxicology (ONETOX) Research Program and the NIH Countermeasures Against Chemical Threats (CounterACT) Program, National Institute of Neurological Disorders and Stroke, USA
4:00 pm
Studies on Air Pollution and Late-Life Neurodegenerative Disorders
Mihye Lee, ScD, Associate Professor of Environmental Health, St. Luke’s International University School of Public Health, Japan
4:30 pm
The Role of Human Aging in Linking Environmental Exposures and Brain Health
Xu Gao, PhD, Assistant Professor, Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, China
5:30 pm
Bus takes attendees to dinner
6:00 pm
Dinner
Wednesday 29 May
8:45 am
Breakfast Available
9:20 am
Welcome
9:30 am
Exposomic Analysis in Two Multiethnic Cohorts of Alzheimer’s Disease
Gary W. Miller, PhD, Vice Dean for Research Strategy and Innovation, and Director, Center for Innovative Exposomics, Columbia University Mailman School of Public Health, USA
10:00 am
Exposome Research for Health Economic Evaluation
Ruoyan Gai, PhD, MSc, Professor, Office of Global Relations, Nagasaki University, Japan
10:30 am
Break
11:00 am
Aging and Frailty among the World Trade Center General Responder Cohort
William Hung, MD, MPH, Professor of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai and Director, Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center (Bronx, NY), USA
11:30 am
Exposomic Mixture Effect: Where Toxicology Meets Chemistry, Epidemiology, and Computer Science
Mingliang Fang, PhD, Professor, Department of Environmental Science and Engineering, Fudan University, China
12:00 pm
Poster Awards
12:30 pm
End of Symposium